Exact and heuristic reactive planning procedures for multi-mode resource-constrained projects.

The multi-mode resource-constrained project scheduling problem (MRCPSP) involves the determination of a baseline schedule of the project activities, which can be executed in multiple modes, satisfying the precedence relations and resource constraints while minimizing the project duration. During the execution of the project, the baseline schedule may become infeasible due to activity duration and resource disruptions. We propose and evaluate a number of dedicated exact reactive scheduling procedures as well as a tabu search heuristic for repairing a disrupted schedule. We report on promising computational results obtained on a set of benchmark problems.Project scheduling; Uncertainty; Reactive scheduling; Multi-mode RCPSP;

RESCON: Educational project scheduling software.

In this article we discuss a freely downloadable educational software tool for illustrating project scheduling and project management concepts. The tool features exact and heuristic scheduling procedures and visualizes project networks, project schedules, resource profiles, activity slacks, and project duration distributions.Project scheduling; Project management; Educational software; Visualization; Scheduling algorithms;

Proactive resource allocation heuristics for robust project scheduling.

The well-known deterministic resource-constrained project scheduling problem (RCPSP) involves the determination of apredictive schedule (baseline schedule or pre-schedule)of the project activities that satisfies the finish-start precedence relations and the renewable resource constraints under the objective of minimizing the project duration. This pre-schedule serves as a baseline for the execution of the project. During execution, however, the project can be subject to several types of disruptions that may disturb the baseline schedule. Management must then rely on a reactive scheduling procedure for revising or reoptimizing the pre-schedule. The objective of our research is to develop procedures for allocating resources to the activities of a given baseline schedule in order to maximize its stability in the presence of activity duration variability. We propose three integer programming based heuristics and one constructive procedure for resource allocation. We derive lower bounds for schedule stability and report on computational results obtained on a set of benchmark problems.Research; Resource allocation; Project scheduling; Heuristics; Scheduling;

Kinetic modeling and graphical analysis of 18F-fluoromethylcholine (FCho), 18F-fluoroethyltyrosine (FET) and 18F-fluorodeoxyglucose (FDG) PET for the discrimination between high-grade glioma and radiation necrosis in rats

Background : Discrimination between glioblastoma (GB) and radiation necrosis (RN) post-irradiation remains challenging but has a large impact on further treatment and prognosis. In this study, the uptake mechanisms of 18F-fluorodeoxyglucose (18F-FDG), 18F-fluoroethyltyrosine (18F-FET) and 18F-fluoromethylcholine (18F-FCho) positron emission tomography (PET) tracers were investigated in a F98 GB and RN rat model applying kinetic modeling (KM) and graphical analysis (GA) to clarify our previous results. Methods : Dynamic 18F-FDG (GB n = 6 and RN n = 5), 18F-FET (GB n = 5 and RN n = 5) and 18F-FCho PET (GB n = 5 and RN n = 5) were acquired with continuous arterial blood sampling. Arterial input function (AIF) corrections, KM and GA were performed. Results : The influx rate (Ki) of 18F-FDG uptake described by a 2-compartmental model (CM) or using Patlak GA, showed more trapping (k(3)) in GB (0.07 min(-1)) compared to RN (0.04 min(-1)) (p = 0.017). K-1 of 18F-FET was significantly higher in GB (0.06 ml/ccm/min) compared to RN (0.02 ml/ccm/min), quantified using a 1-CM and Logan GA (p = 0.036). 18F-FCho was rapidly oxidized complicating data interpretation. Using a 1-CM and Logan GA no clear differences were found to discriminate GB from RN. Conclusions : Based on our results we concluded that using KM and GA both 18F-FDG and 18F-FET were able to discriminate GB from RN. Using a 2-CM model more trapping of 18F-FDG was found in GB compared to RN. Secondly, the influx of 18F-FET was higher in GB compared to RN using a 1-CM model. Important correlations were found between SUV and kinetic or graphical measures for 18F-FDG and 18F-FET. 18F-FCho PET did not allow discrimination between GB and RN

Technical feasibility of [18F]FET and [18F]FAZA PET guided radiotherapy in a F98 glioblastoma rat model

Background: Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolomide (TMZ). An accurate definition of the tumor volume is of utmost importance for guiding RT. In this project we investigated the feasibility and treatment response of subvolume boosting to a PET-defined tumor part. Method: F98 GB cells inoculated in the rat brain were imaged using T2- and contrast-enhanced T1-weighted (T1w) MRI. A dose of 20 Gy (5 x 5 mm(2)) was delivered to the target volume delineated based on T1w MRI for three treatment groups. Two of those treatment groups received an additional radiation boost of 5 Gy (1 x 1 mm(2)) delivered to the region either with maximum [F-18]FET or [F-18]FAZA PET tracer uptake, respectively. All therapy groups received intraperitoneal (IP) injections of TMZ. Finally, a control group received no RT and only control IP injections. The average, minimum and maximum dose, as well as the D-90-, D-50- and D-2- values were calculated for nine rats using both RT plans. To evaluate response to therapy, follow-up tumor volumes were delineated based on T1w MRI. Results: When comparing the dose volume histograms, a significant difference was found exclusively between the D-2-values. A significant difference in tumor growth was only found between active therapy and sham therapy respectively, while no significant differences were found when comparing the three treatment groups. Conclusion: In this study we showed the feasibility of PET guided subvolume boosting of F98 glioblastoma in rats. No evidence was found for a beneficial effect regarding tumor response. However, improvements for dose targeting in rodents and studies investigating new targeted drugs for GB treatment are mandatory

New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma

Abstract The use of O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET) as a positron emission tomography (PET) tracer for brain tumor imaging might have some limitations because of the relatively low affinity for the L-type amino acid transporter 1 (LAT1). To assess the stereospecificity and evaluate the influence of aromatic ring modification of phenylalanine LAT1 targeting tracers, six different fluoroalkylated phenylalanine analogues were synthesized. After in vitro Ki determination, the most promising compound, 2-[18F]-2-fluoroethyl-l-phenylalanine (2-[18F]FELP), was selected for further evaluation and in vitro comparison with [18F]FET. Subsequently, 2-[18F]FELP was assessed in vivo and compared with [18F]FET and [18F]FDG in a F98 glioblastoma rat model. 2-[18F]FELP showed improved in vitro characteristics over [18F]FET, especially when the affinity and specificity for system L is concerned. Based on our results, 2-[18F]FELP is a promising new PET tracer for brain tumor imaging

Resource-constrained project scheduling under uncertainty.

In het probleemdomein van hulpmiddelenbeperkte taaktoewijzing moeten starttijdstippen toegewezen worden aan projectactiviteiten zodat de volgorderelaties tussen de activiteiten gerespecteerd worden, terwijl de beperkte beschikbaarheid van hulpmiddelen (zoals mensen en machines) in geen enkele tijdsperiode mag overschreden worden. Een groot deel van de literatuur inzake projectplanning is gewijd aan deterministische modellen, terwijl in de praktijk de uitvoering van projecten onderhevig is aan vele onzekerheden. Zo kunnen foutieve inschatting van het aantal manuren, machinefaling, ziekte van werknemers, etc. ervoor zorgen dat men afwijkt van het projectplan. Bijgevolg is er een duidelijke nood aan technieken die rekening houden met dit soort onzekerheden. In deze thesis wordt dan ook gefocust op projectplanningsproblemen onder onzekerheid. De thesistekst is als volgt opgebouwd. In een eerste hoofdstuk geven we een inleiding op projectmanagement en -planning. We beschrijven een aantal welbekende deterministische en stochastische projectplanningsomgevingen. We introduceren ook de term projectuitvoeringskosten, hetgeen de objectieffunctie is waarop gefocust zal worden doorheen deze tekst. In Hoofdstuk 2 behandelen we een familie van reactieve planningspolitieken voor het hulpmiddelenbeperkte taaktoewijzingsprobleem met één uitvoeringsmodus per activiteit. Deze politieken kunnen ontplooid worden wanneer variabiliteit in de activiteitsduurtijden het originele projectplan onuitvoerbaar maken. De politieken steunen op vaste hulpmiddelenstromen die aangeven op welke manier hulpmiddelen worden verplaatst van de ene activiteit (wanneer deze voltooid is) naar de andere (wanneer deze aanvangt). In het derde hoofdstuk behandelen we optimale reactieve politieken in het hulpmiddelenbeperkte taaktoewijzingsprobleem waarbij activiteiten meerdere uitvoeringsmodi kunnen hebben, die dan resulteren in verschillende duurtijden en hulpmiddelenvereisten. De reactieve politieken kunnen ontplooid worden wanneer duurtijds- of hulpmiddelenverstoringen het projectplan onuitvoerbaar maken. In Hoofdstuk 4 vestigen we onze aandacht op het stochastische hulpmiddelenbeperkte taaktoewijzingsprobleem. We stellen een procedure voor die een proactieve dynamische uitvoeringspolitiek produceert, die men kan gebruiken om de projectuitvoeringskosten te minimaliseren. Hoofdstuk 5, tenslotte, beschrijft een educatieve softwaretool die we ontwikkeld hebben om onderwerpen gerelateerd aan projectplanning en projectplanning onder onzekerheid te illustreren aan studenten. We beëindigen deze thesistekst met conclusies en onderwerpen voor verder onderzoek.status: publishe

RESCON: Educational project scheduling software

In this article we discuss a freely downloadable educational software tool for illustrating project scheduling and project management concepts. The tool features exact and heuristic scheduling procedures and visualizes project networks, project schedules, resource profiles, activity slacks, and project duration distributions.status: publishe